A Study Protocol for Assessing the Effect of Diode Green Photocoagulation with Rose Bengal in Progressive Infectious Keratitis

Background: Infectious keratitis manifested as corneal ulcer can result in formation of pus in corneal tissue. The incidence has increased in recent years due to overuse of steroids. Infectious keratitis is the most common cause of blindness in India. Rose Bengal proves to be a promising option to treat this condition. Rose Bengal is topical ophthalmic dye which is mildly toxic. It is absorbed by damaged epithelial cells, mucus and fibrous cells. This stain is available in the form of 1% solution or impregnated filter strips. This study aims to assess the duration of resolution of corneal ulcer after Rose Bengal photodynamic therapy.

Methodology: This will be an experimental study carried out at ophthalmology department of AVBRH, Wardha. Total 55 cases will be enrolled and examined on daily basis for one week. Pachymetry and specular microscopy will be done before Rose Bengal Photodynamic Therapy and at the end of three months of treatment.

Results: Resistant infectious keratitis is expected to show complete healing of epithelial defect after receiving photodynamic therapy with green diode laser.