Layne, Dylla and Beau, Abar and Anna-Lise, Williamson and Tracy, L. Meiring and Linda-Gail, Bekker and David, H. Adler (2017) Human papillomavirus clustering patterns among HIV-infected and HIV-uninfected adolescent females in South Africa. Journal of AIDS and HIV Research, 9 (10). pp. 202-206. ISSN 2141-2359
8381F5A66105 - Published Version
Download (512kB)
Abstract
The global burden of disease caused by both human immunodeficiency virus (HIV) and human papillomavirus (HPV) is the greatest in the developing world, with the highest rates in sub-Saharan Africa. South African women not only have high rates of infection with HPV, but also have high rates of multiple concurrent infections with two or more HPV genotypes, and are among the world’s most vulnerable to developing invasive cervical cancer. HIV co-infection increases these risks. Understanding clustering patterns of concurrent HPV infections in this population has important implications for HPV screening and will help define vaccination strategies in the future as vaccines continue to be developed to target more HPV genotypes. Latent class analysis was used to identify four distinct patterns of HPV co-infection: individuals with at least one low risk HPV genotype, but no high-risk HPV (HR-HPV) infections; individuals with a disperse pattern of HR-HPV infections; individuals infected with members of the alpha-7 group, but not HPV-18; and individuals infected with HPV-16, but not HPV-18. In this analysis, although alpha-7 HPV infections were more prevalent among HIV-infected adolescents than their HIV-uninfected counterparts, overall clustering patterns were not different based on HIV status.
Item Type: | Article |
---|---|
Subjects: | South Asian Archive > Medical Science |
Depositing User: | Unnamed user with email support@southasianarchive.com |
Date Deposited: | 14 Apr 2023 09:30 |
Last Modified: | 28 May 2024 05:44 |
URI: | http://article.journalrepositoryarticle.com/id/eprint/551 |